virus
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Nanotechnology
Scientists develop nanobody inhibitor to target deadly Ebola virus
Structural basis of anti-EBOV function of Nanosota-EB1. (A) Cryo-EM structure of EBOV GP-ΔM in complex with Nanosota-EB1 (top view, surface view). The three subunits of EBOV GP-ΔM are colored orange, gray, and green, respectively. Nanosota-EB1 is shown in blue. Two Nanosota-EB1 molecules are bound to the trimeric GP-ΔM. (B) Cryo-EM structure (side view) of EBOV GP-ΔM in complex with Nanosota-EB1.…
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Nanotechnology
AI-designed ‘nanocage’ mimics virus behavior to enhance gene therapy
Cryo-EM analysis of the designed novel protein nanocage. Credit: POSTECH Researchers have developed an innovative treatment platform by using artificial intelligence (AI) to mimic the complex structure of the virus. Their pioneering research was published in the journal Nature on December 18th. Viruses are uniquely designed to encapsulate genetic material within a spherical protein shell, allowing the virus to replicate…
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Science
Capybara found dead from rabies on Brazilian island, highlighting the need for virus surveillance
A young capybara with paralyzed hind legs was photographed days before dying from rabies encephalitis on Anchieta Island, near the coast of São Paulo. Credit: Fundação Florestal Between December 2019 and January 2020, three capybaras (Hydrochoerus hydrochaeris) died from rabies on Anchieta Island in Ubatuba, São Paulo state, Brazil. One dog was found dead and two showed paralysis in their…
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Biology
Mosquito genetics may explain why Zika virus outbreaks are rare in Africa: climate change could shift the balance
Mosquitoes that bite people. Credit: Greg Murray / Louis Lambrechts Africa’s low incidence of the Zika virus may be due to a surprising factor: the genetic makeup of local mosquito populations, a study has found. Research by scientists at Princeton University’s High Meadows Environmental Institute (HMEI), the Pasteur Institute, and the University of California, San Diego, reveals the causes of…
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Biology
New strategies needed to fight immune system-damaging poultry virus detected on UK farms
HVR-based phylogenetic tree of the VP2 gene encoded by segment A. Credit: Virology (2024). DOI: 10.1016/j.virol.2024.110269 Researchers working to understand the spread of the virus, which can severely damage chickens’ immune systems, say new strategies are needed to improve control of the disease in the UK. . Dr Vishi Reddy from Keele University was one of the researchers on a…
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