untreatable

Chemistry

Scientists discover chemical probe for previously ‘untreatable’ cancer target

Structural models predict that the small molecule binding site on FOXA1 is close to DNA. Credit: Scripps Research Cancers caused by hormones, such as breast and prostate cancers, often rely on a difficult-to-target protein called forkhead box protein 1 (FOXA1). FOXA1 mutations may enable these types of cancers to grow and proliferate. Currently, FOXA1 is notoriously difficult to block with…