tumors
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Nanotechnology
Engineers develop methods to mass-produce nanoparticles that will directly supply cancer drugs to tumors
This microfluidic device can be used to quickly and in large quantities of nanoparticles. Credit: Gretchen Ertl Nanoparticles coated with therapeutic agents show great promise in cancer treatments, including ovarian cancer. These particles can directly target tumors, where they release the payload while avoiding many of the side effects of traditional chemotherapy. Over the past decade, Professor Paula Hammond of…
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Nanotechnology
Remove hidden cancer messengers: How extracellular vesicles help spread tumors
This graphic shows paracrine adhesion signaling in small extracellular vesicles. It secretes a protein called galectin-3. This promotes endocytosis so that the vesicles can be absorbed into recipient cells. Credit: Suzuki Kenichi et al. , Gifu University Most cells in the body send out small messengers called extracellular vesicles that carry proteins, lipids, and other biologically active molecules to other…
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Nanotechnology
Pre-chemotherapy tumor-derived nanovaccine fights multiple tumors in mice
Schematic representation of the dual role of nanotechnology in enhancing personalized tumor vaccine therapy in combination with neoadjuvant chemotherapy. Credit: Nie Guangjun et al. A research team led by Professor Nie Guangjun from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS) and collaborators have demonstrated a tumor membrane antigen-based nanovaccine derived from liposomal…
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Nanotechnology
Biodegradable nanoparticles enable simultaneous delivery of two drugs to attack tumors
Talazoparib increased PD-L1 expression levels and P-selectin expression evaluation in human and mouse melanomas and BRCA-mutant mouse BC. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adr4762 Researchers at Tel Aviv University have developed a new platform that uses polymer nanoparticles to deliver drug pairs to specific types of cancer, such as skin cancer and breast cancer. The researchers explain that having both…
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Nanotechnology
New nanocatalyst targets tumors without oxygen
Structure and biological mechanism of action of NP4 on tumor-targeted glutathione (GSH) oxidation catalyst in hypoxic osteosarcoma tumors. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-53646-y Tumors often contain areas of oxygen-deficient tissue that do not tolerate conventional treatments. This is because drugs applied to tumors require oxygen to be effective. An international research team has developed a new mechanism of action…
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