treatment
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Biology
Computational models enhance protein kinase target predictions for treatment
Success rates of single target RF models in predicting kinase inhibitory activity of selected eight compounds. Success rates represent the percentage of correctly predicted kinase activity obtained for each compound for 20 experimentally tested targets. Credit: International Journal of Molecular Sciences (2025). doi:10.3390/ijms26052157 Research on protein kinases provides an opportunity to explore molecular targets in the body to treat diseases…
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Nanotechnology
Precision cancer treatment using magnet-induced thermally activated nanoparticles
The schematic diagram of the nanoparticles (above) shows that magnetic ionic liquids (yellow circles), fluorescent dyes (pink star), and polyethylene glycol coatings are integrated into the carbon nanohorns. In animal testing, nanoparticles are directed towards tumor cells with magnets, allowing tumors to be eliminated after laser treatment (bottom). Credit: Eijiro Miyako of Jaist Traditionally, radiation, chemotherapy, and surgery have been…
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Nanotechnology
Nanoparticles supply microRNAs to muscle stem cells for potential muscular dystrophy treatment
Immunofluorescence staining of skeletal muscle from mice treated with microearn nanoparticles. Credit: Alvaro Somosa In international collaboration, researchers have made important breakthroughs in the therapeutic delivery of microRNAs against the previously untreated disease, Duchenne muscular dystrophy. Duchenne muscular dystrophy is a hereditary disorder characterized by progressive loss of muscle mass due to mutations in the dystrophin gene. Without the corresponding…
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Nanotechnology
Nano particles coated with peptides achieve 98% of drug filling rates and improve cancer treatment.
High filling peptide drug nanoparticle. Credit: Rein Ulijn The scientist team has developed a groundbreaking approach to improve the preparation using a specially designed peptide. This innovative method greatly enhances the antitumor effect, as it has been demonstrated by a leukemia model. The study in the CHEM magazine was led by the New York State University Graduate School of State…
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Nanotechnology
Nanoliposomes pave the way for treatment of rare genetic diseases
Indication of new nanoGLA therapy. We demonstrate its composition and structure by cryomicroscopic imaging. NanoGLA has been injected into mice and has orphan drug designation. Credit: ICMAB An international research team has developed a new nanotechnology-based therapy called nanoGLA for the treatment of Fabry disease. This new treatment has shown significant efficacy in preclinical studies. The study was published in…
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Nanotechnology
Delivering mRNA- and RNAi-based therapies in a single treatment has the potential to fight complex diseases
Simultaneous gene recovery and knockdown with single-drug NPs and co-delivered dual-drug NPs using mRNA and siRNA in two cell lines. Credit: ACS Nanoscience Au (2024). DOI: 10.1021/acsnanoscienceau.4c00040 Researchers at the University of Ottawa may have cracked the code for harnessing both mRNA and RNAI-based therapies to improve treatments for cancer, cardiovascular disease and other complex diseases. The success of COVID-19…
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Biology
Targeting bacterial defense mechanisms for effective antibiotic treatment
Possible causes of mortality upon loss of membrane potential. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-51347-0 In addition to the urgent need for new antibiotics, alternative strategies are also needed to tackle the problem of antibiotic resistance. Associate Professor Michaela Wenzel of Chalmers University of Technology studies bacterial defenses against external stress and targets these for efficient antibiotic treatments. Michaela Wenzel…
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Nanotechnology
Light-activated drug-loaded liposomes show potential for minimally invasive glaucoma treatment
Credit: CC0 Public Domain More than 4 million people in the United States have glaucoma. Glaucoma is a group of eye diseases that can damage the optic nerve and lead to vision loss. It is the second leading cause of blindness worldwide, and while there is currently no cure, there are ways to prevent vision loss through early detection and…
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Nanotechnology
Scientists develop copper depletion strategy for advanced cuprococcal disease treatment
Credit: Chemical Sciences (2024). DOI: 10.1039/D4SC04712E A research team from Nanjing University introduced an innovative approach to copper ptosis treatment by depleting copper levels within tumor cells, challenging the current paradigm focused on copper overproduction. The study, published in the journal Chemical Science, uses mesoporous zinc sulfide (ZnS) nanoparticles as “copper nanoconsumers” to efficiently remove copper ions from cancer cells.…
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Nanotechnology
Nanoparticle-based approach targets inflammatory cells for obesity treatment
Credit: Unsplash/CC0 Public Domain As reported in a recent study published in ACS Nano, researchers at the Terasaki Institute for Biomedical Innovation have developed a new nanoparticle-based therapy for the treatment of obesity. This innovative approach targets inflammatory cells in adipose tissue, modulates the immune system, and promotes browning of adipose tissue. This study addresses the global obesity epidemic and…
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