topology

Biology

Introducing HORNET, a new RNA structure visualization method that correlates sequence and 3D topology

AFM images and initial models of BM3, BM4, and BM5. Credit: Nature (2024). DOI: 10.1038/s41586-024-07559-x Researchers at the National Cancer Institute have developed a method called HORNET to characterize the 3D topological structure of large, flexible RNA molecules. The scientists used atomic force microscopy (AFM) with deep neural networks and unsupervised machine learning to capture individual conformers under physiological conditions.…