therapy
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Nanotechnology
Nanomachines with wine ingredients overcome the challenges of gene therapy
Nanocomposites are constructed by continuous mixing of AAV9, TA, and polymers in aqueous solutions. The nanocomplexes released loaded AAVs into the cells, indicating efficient genetic transduction into the cells. Upon intravenous injection, the AAV ternary complex successfully avoided NABS. Credit: Uto Honda Researchers will be the first in the world to use mice to overcome the key challenges of gene…
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Nanotechnology
Inhalation therapy uses mussel-derived nanoparticles to target lung cancer cells
Schematic representation of an inhalable mucoadhesive nanoanticancer drug based on mussel adhesion proteins (top) and therapeutic results in a lung cancer animal model (bottom). Credit: POSTECH Researchers from POSTECH and Kyungpook National University have developed a new inhalable treatment delivery system for lung cancer that leverages mucoadhesive protein nanoparticles inspired by the adhesive properties of marine shellfish. Lung cancer remains…
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Nanotechnology
AI-designed ‘nanocage’ mimics virus behavior to enhance gene therapy
Cryo-EM analysis of the designed novel protein nanocage. Credit: POSTECH Researchers have developed an innovative treatment platform by using artificial intelligence (AI) to mimic the complex structure of the virus. Their pioneering research was published in the journal Nature on December 18th. Viruses are uniquely designed to encapsulate genetic material within a spherical protein shell, allowing the virus to replicate…
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Nanotechnology
Nanoparticle-mediated gene therapy addresses a major cause of stillbirth and premature birth in guinea pig models
Dogs, cats, guinea pigs, rabbits, and ferrets have been taken to veterinary hospitals with heat stroke. Credit: Pixabay/CC0 Public Domain Billions of people living on Earth owe their lives to the temporary organs that supported and nourished them in their mothers’ wombs. The placenta, or afterbirth, is considered sacred in some cultures, and its vital role in pregnancy has been…
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Nanotechnology
Engineers refine lipid nanoparticles for better mRNA therapy
Chemical evolution of A3 lipids driven by A3 coupling reactions and activity and degradability. Credit: Nature Biomedical Engineering (2024). DOI: 10.1038/s41551-024-01267-7 Penn engineers have devised a new method to improve mRNA delivery and developed an optimal “recipe” for ionized lipids, the key ingredient in lipid nanoparticles (LNPs). This is the molecule behind COVID-19 vaccines and other innovative treatments. The method,…
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Nanotechnology
Scientists design stable protein complexes for targeted cancer therapy
Credit: ACS Nano (2024). DOI: 10.1021/acsnano.4c09220 Auburn University researchers, in partnership with the University of Basel in Switzerland, have discovered a new way to make cancer-targeting protein complexes more stable, opening the door to better cancer treatments. . The study, led by Dr. Rafael Bernardi of Auburn University’s Department of Physics and Dr. Michael Nash of the Department of Chemistry…
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Nanotechnology
Drug delivery system overcomes circulatory obstacles that prevent gene therapy from reaching its target
Graphical summary. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.07.023 Harnessing the remarkable ability of viruses to deliver gene therapy across previously circulatory obstacles is at the heart of a University of Alberta-led discovery that promises to reinvigorate the field of genetic medicine. John Lewis, an oncologist in the School of Medicine and Dentistry and lead author of the study describing this advance,…
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Science
Researchers study light and ultrasound therapy for melanoma treatment in pigs
Dr. Jennifer Fridley, director of the Texas A&M University Veterinary Medical Park, is collaborating on a melanoma treatment study exploring phototherapy and ultrasound therapy to fight skin cancer in pigs. Credit: Texas A&M University Texas A&M University researchers are collaborating on a new project to study how ultrasound and light can treat melanoma in pigs. Recent medical advances have made…
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Nanotechnology
Nanoparticle therapy brings new hope to prostate cancer patients
The wavelength of 810 nm is optimal for energy absorption/excitation of nanoshells (orange) compared to hemoglobin (red) and water (blue). The nanoshell diameter is approximately 150 nm, which is 46 times smaller than a red blood cell (RBC). NIR refers to near-infrared rays. Credit: Journal of Urology (2024). DOI: 10.1097/JU.0000000000004222 Prostate cancer is the second leading cause of cancer death…
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