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Earth
Research warns that carbon dioxide rate of rise is ‘incompatible’ with 1.5℃ target
Credit: Unsplash/CC0 Public Domain Carbon dioxide in the atmosphere is increasing at a rate that is incompatible with keeping global warming below 1.5 degrees Celsius (34.7 degrees Fahrenheit), a Japan Meteorological Agency study warns. Concentrations of major greenhouse gases rose in 2024 at the fastest annual level in a long-term record of measurements at Hawaii’s Mauna Loa, which dates back…
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Nanotechnology
Inhalation therapy uses mussel-derived nanoparticles to target lung cancer cells
Schematic representation of an inhalable mucoadhesive nanoanticancer drug based on mussel adhesion proteins (top) and therapeutic results in a lung cancer animal model (bottom). Credit: POSTECH Researchers from POSTECH and Kyungpook National University have developed a new inhalable treatment delivery system for lung cancer that leverages mucoadhesive protein nanoparticles inspired by the adhesive properties of marine shellfish. Lung cancer remains…
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Nanotechnology
Scientists develop nanobody inhibitor to target deadly Ebola virus
Structural basis of anti-EBOV function of Nanosota-EB1. (A) Cryo-EM structure of EBOV GP-ΔM in complex with Nanosota-EB1 (top view, surface view). The three subunits of EBOV GP-ΔM are colored orange, gray, and green, respectively. Nanosota-EB1 is shown in blue. Two Nanosota-EB1 molecules are bound to the trimeric GP-ΔM. (B) Cryo-EM structure (side view) of EBOV GP-ΔM in complex with Nanosota-EB1.…
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Nanotechnology
Drug delivery system overcomes circulatory obstacles that prevent gene therapy from reaching its target
Graphical summary. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.07.023 Harnessing the remarkable ability of viruses to deliver gene therapy across previously circulatory obstacles is at the heart of a University of Alberta-led discovery that promises to reinvigorate the field of genetic medicine. John Lewis, an oncologist in the School of Medicine and Dentistry and lead author of the study describing this advance,…
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Chemistry
Scientists discover chemical probe for previously ‘untreatable’ cancer target
Structural models predict that the small molecule binding site on FOXA1 is close to DNA. Credit: Scripps Research Cancers caused by hormones, such as breast and prostate cancers, often rely on a difficult-to-target protein called forkhead box protein 1 (FOXA1). FOXA1 mutations may enable these types of cancers to grow and proliferate. Currently, FOXA1 is notoriously difficult to block with…
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