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Chemistry
A simple model system can disassemble fibrils and study therapeutic drugs for neurodegenerative diseases
Credit: Journal of the American Chemical Society (2024). DOI: 10.1021/jacs.4c11285 The causes of many diseases, such as Alzheimer’s disease and Parkinson’s disease, are found at the molecular level, or proteins, in our bodies. In healthy systems, these proteins are responsible for numerous physiological functions. They can also assemble into groups of many proteins to perform specific tasks. Once the job…
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Space & Cosmos
Carbon-storing molecules discovered in distant interstellar clouds may shed light on how our own solar system formed
The Taurus Molecular Cloud, where TMC-1 is located, appears at the top of the image as a dark cloud blocking light from background stars, as seen from Charlottesville, Virginia. Credit: Brett A. McGuire A team led by MIT researchers has discovered that distant interstellar clouds are rich in pyrene, a type of large carbon-containing molecule known as polycyclic aromatic hydrocarbons…
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Nanotechnology
Drug delivery system overcomes circulatory obstacles that prevent gene therapy from reaching its target
Graphical summary. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.07.023 Harnessing the remarkable ability of viruses to deliver gene therapy across previously circulatory obstacles is at the heart of a University of Alberta-led discovery that promises to reinvigorate the field of genetic medicine. John Lewis, an oncologist in the School of Medicine and Dentistry and lead author of the study describing this advance,…
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Other Sciences
Victims of national scandals are further harmed by compensation system
Credit: Pixabay/CC0 Public Domain Researchers at King’s College London say victims of state scandals are disappointed and dissatisfied with the current compensation system, which is “exacerbating the harm they have already suffered”. They are calling for the creation of new public institutions to ensure fair and independent outcomes for victims, and mandatory guidance on the setting up and operation of…
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Earth
Capturing finer-scale topographic differences improves the ability of Earth system models to reproduce observations
Spatial pattern of number of topographic units (TGU) per 0.5 degree grid. We demonstrate the ability of a terrain-based subgrid structure to capture terrain heterogeneity across a mountainous region and associated data that is a measure of the computational efficiency of the data reduction metric (DRM). We define a variable number of TGUs per grid in conjunction with the allocation…
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Physics
Scientists demonstrate advanced low-coherence BOCDR system using periodic pseudorandom modulation
This figure shows the results of distributed strain sensing over a length of approximately 100 m of optical fiber utilizing BOCDR with periodic pseudorandom modulation. The diagram above shows the structure of the sensing fiber, which includes two tightly wound 47-meter sections and a 10-centimeter taut section near the end. The middle plot shows the distributed Brillouin frequency shift along…
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