synthesis
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Chemistry
Drum Mill achieves kilogram-scale ibuprofen synthesis with environmentally friendly technology
Co-crystal powder (rac-ibuprofen nicotinamide) and milling ball IMPACTIVE. Credit: Jan-Hendrik Schöbel For the first time, researchers have used a drum mill to produce kilograms of ibuprofen-nicotinamide, a formulation that improves therapeutic efficacy and stability. This is part of the European project IMPACTIVE, which focuses on researching mechanochemical methods to make pharmaceutical manufacturing more sustainable and reduce both carbon emissions and…
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Nanotechnology
Highly tunable biotemplating methods expand options for nanostructure synthesis
CamBio uses microtubules, which are protein structures inside cells. The silver nanoparticle chains synthesized along microtubules extending throughout the cell interior could be observed using electron microscopy, indicating that they can be used as SERS substrates. Credit: Advanced Science (2024). DOI: 10.1002/advs.202406492 The joint research team developed a highly tunable biotemplate method that utilizes specific internal proteins in biological samples.…
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Chemistry
Universal barcodes enable fast small molecule synthesis
Commonalities outline a roadmap to rapid analysis. Credit: Nature (2024). DOI: 10.1038/s41586-024-08211-4 The development of molecules to study and treat diseases is increasingly burdened by the time and specificity required to analyze the vast amounts of data generated by synthesizing large collections of new molecules. It’s taking place. Scientists at St. Jude Children’s Research Hospital present a new solution to…
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Chemistry
Abiotic organic synthesis research suggests new mechanism of organic condensation
Manned Vehicle (HOV) Shen Hai Yongshi. Credit: NIGPAS A Chinese research team reported the discovery of abiotic organic compounds in the oceanic crust of the Southwest India Ridge and proposed a molecular mechanism for organic condensation. This groundbreaking discovery follows the discovery in 2021 of nanoscale abiotic organic matter in mantle rocks in the Yap Trench. This represents an important…
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