ribozyme

Biology

Testing of thousands of RNA enzymes discovers first ‘Twister ribozyme’ in mammals

A novel cleavage high-throughput assay (CHiTA) developed at Penn State University provides a flawless method to characterize thousands of diverse small self-cleaving RNA enzymes called Twister ribozymes in a single experiment. This image shows 2D models of some of the ribozymes tested that had defects in the helical and loop elements but still remained active, demonstrating that the Twister ribozyme’s…