refine

Nanotechnology

Engineers refine lipid nanoparticles for better mRNA therapy

Chemical evolution of A3 lipids driven by A3 coupling reactions and activity and degradability. Credit: Nature Biomedical Engineering (2024). DOI: 10.1038/s41551-024-01267-7 Penn engineers have devised a new method to improve mRNA delivery and developed an optimal “recipe” for ionized lipids, the key ingredient in lipid nanoparticles (LNPs). This is the molecule behind COVID-19 vaccines and other innovative treatments. The method,…