proteins
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Biology
Scientists reveal how proteins associated with Parkinson’s disease convert biomolecular condensates
Professor Zheng Shi, an assistant professor at Rutgers University, and a doctoral student at both the Faculty of Chemical and Chemistry Biology, Huan Wang employs specialized tools to explore the properties of mysterious substances known as biomolecular condensates. Credit: Zheng Shi/Rutgers University An international research collaboration led by New Brunswick scientists at Rutgers University who examined microscopic blobs of proteins…
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Chemistry
Proteins can mistakenly use Lassos itself to help explain abnormal modification behaviors
It is one of the naturally folded structures of the protein phosphoglycerate kinase (PGK) on the left and one of the misfolded PGK structures predicted in this study on the right, with the entangled regions highlighted in red and blue. Credit: Jan Jang, Pennsylvania Proteins are long molecules that need to fold into complex three-dimensional structures to perform cellular functions.…
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Chemistry
Palladium-mediated reactions enable precise engineering of peptides and proteins
1 is a schematic diagram showing the preparation of fluorophore-labeled ubiquitin (top) and the chemical structure (bottom) of analogs of gordosporin, a narrow range of antibiotics against gram-positive bacteria. Both transformations were enabled by binding reactions developed by the authors. Credit: National University of Singapore Pharmaceutical scientists at the National University of Singapore (NUS) have developed a new chemical reaction…
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Nanotechnology
Self-sealing, Atomic Thin Dialysis Membranes: Proteins convert leaks into filtration benefits
Graphical abstract. Credit: Nano Letter (2024). doi: 10.1021/acs.nanolett.4c04706 The Vanderbilt-led research team has made a major breakthrough in the development of advanced dialysis membranes using atomically thin materials such as graphene. These innovative membranes, called nanoporous atomic thin films (NATMs), utilize protein-enabled sealing mechanisms to maintain high efficiency in filtration of small molecules while minimizing protein loss. Addressing important issues.…
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Chemistry
Researchers highlight the role ‘workhorse proteins’ play in keeping the nervous system running smoothly
Hsc70 retards SNAP-25 aggregation. Aggregation kinetics of SNAP-25 (50 μM) at 37 °C. The optical density of SNAP-25 was recorded at 360 nm in the absence (black) and presence of Hsc70 (5 μM, red) and Hsc70+CSPαJ (5 μM each, blue). Hsc70 (gray) and CSPαJ (dark gray) alone do not show aggregation. Credit: Journal of Biological Chemistry (2024). DOI: 10.1016/j.jbc.2024.108001 A…
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Nanotechnology
Machine learning and supercomputer simulations predict interactions between gold nanoparticles and blood proteins
Cover image of Bioconjugate Chemistry October 2024 issue. Tunable ligand-protected gold as a drug delivery system with high affinity for integrin αvβ3, a key regulator of adhesion and signaling in various biological processes that play important roles in cancer. Showing nanoclusters. Progress. Credit: María Francisca Matus, University of Jyväskylä. Researchers at the Center for Nanoscience at the University of Jyväskylä…
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Chemistry
Studying membrane proteins using genetic code extensions
Protein labeling strategy. Credit: Chemical Reviews (2024). DOI: 10.1021/acs.chemrev.4c00181 Over the years, chemical biology techniques have made important contributions to the study of integral membrane proteins. An important modern approach is genetic code expansion (GCE), which allows proteins to be directly modified in living cells to confer customized properties. Professor Irene Coyne of the University of Leipzig is a pioneer…
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Nanotechnology
Nanoparticle approach enhances detection of low-abundance proteins in plasma
PtdChos can deplete the most abundant plasma proteins in the protein corona profile. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-53966-z In a recent study published in Nature Communications, scientists from Karolinska Institutet’s Department of Microbiology, Tumors and Cell Biology, in collaboration with Michigan State University, introduced an innovative approach to improve plasma proteome profiling. Researchers have developed a new method that…
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Chemistry
Glowing proteins enable real-time 3D studies of essential enzymes
Graphical summary. Credit: Nature Chemical Biology (2024). DOI: 10.1038/s41589-024-01758-3 Researchers at the University of California, San Diego School of Medicine have developed a new tool to use organoid models to study the protein kinase C (PKC) enzyme, which plays a critical role in cell growth, differentiation, and survival. Dysfunction of these proteins has been linked to many human diseases, including…
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