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Chemistry
Novel platinum complex exhibits potent antiproliferative effects with low toxicity in preclinical prostate cancer models
Binuclear platinum(II) complex inhibits prostate cancer cell proliferation by binding to androgen receptor (AR) and interfering with AR-mediated gene expression. This mechanism causes apoptosis and prevents cell proliferation induced by dihydrotestosterone (DHT). Credit: Yoshihisa Hirota / SIT, Japan. DOI: 10.1021/acs.inorgchem.4c01093 Prostate cancer remains a global health challenge, ranking as the second most commonly diagnosed cancer among men. Although treatments such…
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Chemistry
Designing long-lived peptides for more potent drugs
Diagram of helical wheel. (A) K47; (B) K311. Helical wheel generated using HeliQuest (https://heliquest.ipmc.cnrs.fr/). (C) Sequences of K47 and K311 aligned with heptad abcdefg and hendecad abcdefghijk registers. Credit: Biomacromolecules (2024). DOI: 10.1021/acs.biomac.4c00661 Peptides may appear and disappear too quickly. These series of amino acids, the building blocks of life, are of intense interest to researchers because of their potential…
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