platinum

Chemistry

Novel platinum complex exhibits potent antiproliferative effects with low toxicity in preclinical prostate cancer models

Binuclear platinum(II) complex inhibits prostate cancer cell proliferation by binding to androgen receptor (AR) and interfering with AR-mediated gene expression. This mechanism causes apoptosis and prevents cell proliferation induced by dihydrotestosterone (DHT). Credit: Yoshihisa Hirota / SIT, Japan. DOI: 10.1021/acs.inorgchem.4c01093 Prostate cancer remains a global health challenge, ranking as the second most commonly diagnosed cancer among men. Although treatments such…