Nanoparticles
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Nanotechnology
Precision cancer treatment using magnet-induced thermally activated nanoparticles
The schematic diagram of the nanoparticles (above) shows that magnetic ionic liquids (yellow circles), fluorescent dyes (pink star), and polyethylene glycol coatings are integrated into the carbon nanohorns. In animal testing, nanoparticles are directed towards tumor cells with magnets, allowing tumors to be eliminated after laser treatment (bottom). Credit: Eijiro Miyako of Jaist Traditionally, radiation, chemotherapy, and surgery have been…
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Nanotechnology
Nanoparticles supply microRNAs to muscle stem cells for potential muscular dystrophy treatment
Immunofluorescence staining of skeletal muscle from mice treated with microearn nanoparticles. Credit: Alvaro Somosa In international collaboration, researchers have made important breakthroughs in the therapeutic delivery of microRNAs against the previously untreated disease, Duchenne muscular dystrophy. Duchenne muscular dystrophy is a hereditary disorder characterized by progressive loss of muscle mass due to mutations in the dystrophin gene. Without the corresponding…
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Nanotechnology
Nanoparticles provide the plant with genetic material normally through its roots
Uptake of LDH nanoparticles in the roots of N. Benthamiana. Credit: Natural Plants (2025). doi:10.1038/s41477-024-01882-x Researchers at the University of Queensland have first introduced genetic material into plants via roots, opening up potential pathways for rapid crop improvement. This study is published in Nature Plants. Professor Bernard Carroll of UQ’s Chemistry and Molecular Biosciences said nanoparticle technology can help fine-tune…
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Nanotechnology
Solving the drug solubility problem with silica nanoparticles
Adsorption of APIs and water molecules on silica surfaces of different silica densities. Credit: Proceedings of the National Academy of Sciences (2025). doi:10.1073/pnas.2423426122 Researchers at Harvard University and Hong Kong China University have developed methods that increase the solubility of drug molecules up to three orders of magnitude. This could be a breakthrough in drug formulations and delivery. Over 60%…
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Nanotechnology
Nanoparticles restore Parkinson’s disease neurons with wireless brain stimulation
A practical model demonstrating wireless DBS mediated by ATB NPs to reverse PD. Credit: Science Advances (2025). DOI: 10.1126/sciadv.ado4927 Parkinson’s disease (PD) is the second most common neurodegenerative disease and is primarily characterized by motor dysfunction. Its pathological hallmark is the abnormal aggregation of α-synuclein (α-syn) into insoluble fibrils and Lewy bodies, which causes degeneration and death of dopaminergic neurons…
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Nanotechnology
Inhalation therapy uses mussel-derived nanoparticles to target lung cancer cells
Schematic representation of an inhalable mucoadhesive nanoanticancer drug based on mussel adhesion proteins (top) and therapeutic results in a lung cancer animal model (bottom). Credit: POSTECH Researchers from POSTECH and Kyungpook National University have developed a new inhalable treatment delivery system for lung cancer that leverages mucoadhesive protein nanoparticles inspired by the adhesive properties of marine shellfish. Lung cancer remains…
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Nanotechnology
Specially delivered nanoparticles can program stem cells while in the body
After injecting 105 LNPs, we isolated the Lin- population from bone marrow, quantified LNPs (barcodes), functional delivery (aVHH proteins), and cell identity (transcriptome) in single cells, and analyzed the data. were superimposed. Credit: Nature Biotechnology (2024). DOI: 10.1038/s41587-024-02470-2 Intermediaries get a bad rap for adding cost and complexity to surgeries. Therefore, eliminating intermediaries reduces expenses, simplifies processes, and increases efficiency…
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Nanotechnology
Biodegradable nanoparticles enable simultaneous delivery of two drugs to attack tumors
Talazoparib increased PD-L1 expression levels and P-selectin expression evaluation in human and mouse melanomas and BRCA-mutant mouse BC. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adr4762 Researchers at Tel Aviv University have developed a new platform that uses polymer nanoparticles to deliver drug pairs to specific types of cancer, such as skin cancer and breast cancer. The researchers explain that having both…
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Nanotechnology
Engineers refine lipid nanoparticles for better mRNA therapy
Chemical evolution of A3 lipids driven by A3 coupling reactions and activity and degradability. Credit: Nature Biomedical Engineering (2024). DOI: 10.1038/s41551-024-01267-7 Penn engineers have devised a new method to improve mRNA delivery and developed an optimal “recipe” for ionized lipids, the key ingredient in lipid nanoparticles (LNPs). This is the molecule behind COVID-19 vaccines and other innovative treatments. The method,…
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Nanotechnology
Machine learning and supercomputer simulations predict interactions between gold nanoparticles and blood proteins
Cover image of Bioconjugate Chemistry October 2024 issue. Tunable ligand-protected gold as a drug delivery system with high affinity for integrin αvβ3, a key regulator of adhesion and signaling in various biological processes that play important roles in cancer. Showing nanoclusters. Progress. Credit: MarÃa Francisca Matus, University of Jyväskylä. Researchers at the Center for Nanoscience at the University of Jyväskylä…
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