mRNA
-
Nanotechnology
A novel class of zwitterionic phospholipids promotes mRNA delivery
Polar electron microscope images of lipid suspensions composed of DOPE-C8 and POPC. Credit: Advanced Science (2025). doi:10.1002/advs.202413016 A new study conducted by researchers at Hokkaido University has announced a new class of zwitterionic phospholipids that can significantly enhance the functional delivery of mRNAs. This study was published in Advanced Science. The new phospholipid, dope CX, was derived from a compound…
Read More » -
Nanotechnology
Combined organ-specific mRNA and lipid nanoparticle therapy may repair damaged lungs
Cell-specific expression of TGF-βMRNA-IAJD34 in the lungs over time. Credit: Natural Communication (2025). doi:10.1038/s41467-025-56448-y A combination of mRNA and new lipid nanoparticles could help heal damaged lungs, according to a new study from the University of Pennsylvania Perelman School of Medicine. Viruses, physical trauma, or other issues can have serious effects on the lungs, and traditional treatments like inhaled medications…
Read More » -
Science
Next-generation mRNA vaccine delivery system uses biodegradable polymers
Schematic representation of MRNA expression, T cell immune activation, and neutralizing antibody formation induced by polymers synthesized from a variety of monomers. Credit:Postech The research team at Postech has developed a biodegradable polymer-based delivery system that efficiently transports mRNA. This study was recently published in Biomaterials. Since the Covid-19 pandemic, global interest in mRNA vaccines has skyrocketed. Among existing delivery…
Read More » -
Nanotechnology
End -Some Escape: Improve LNP MRNA to bend lipids and gene editing
The new lipid sample improves the success rate of the lipid nanoparticle that supplies the contents. Credit: sylvia zhang Every time a shuttle is docked by the International Space Station (ISS), a delicate dance develops between the shuttle docking system and the station counter part. Thanks to international standards, these mechanisms are universally compatible, so that astronauts and cargo can…
Read More » -
Nanotechnology
Delivering mRNA- and RNAi-based therapies in a single treatment has the potential to fight complex diseases
Simultaneous gene recovery and knockdown with single-drug NPs and co-delivered dual-drug NPs using mRNA and siRNA in two cell lines. Credit: ACS Nanoscience Au (2024). DOI: 10.1021/acsnanoscienceau.4c00040 Researchers at the University of Ottawa may have cracked the code for harnessing both mRNA and RNAI-based therapies to improve treatments for cancer, cardiovascular disease and other complex diseases. The success of COVID-19…
Read More » -
Nanotechnology
Engineers refine lipid nanoparticles for better mRNA therapy
Chemical evolution of A3 lipids driven by A3 coupling reactions and activity and degradability. Credit: Nature Biomedical Engineering (2024). DOI: 10.1038/s41551-024-01267-7 Penn engineers have devised a new method to improve mRNA delivery and developed an optimal “recipe” for ionized lipids, the key ingredient in lipid nanoparticles (LNPs). This is the molecule behind COVID-19 vaccines and other innovative treatments. The method,…
Read More » -
Science
Unique mRNA delivery method could repair defective genes before birth
In utero delivery of Cas9 mRNA/gRNA by ADP-LNP leads to extensive cell editing in the fetal brain. Credit: University of California, Davis New research shows that biomedical tools can successfully deliver genetic material to edit defective genes in developing fetal brain cells. The technology, tested in mice, could halt the progression of genetically based neurodevelopmental conditions such as Angelman syndrome…
Read More »
