Microscopy
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Chemistry
Enhanced Raman microscopy enables clearer chemical imaging of cryofixed samples
Raman image of snap-frozen HeLa cells with high signal-to-noise ratio and wide field of view. Image acquisition time was 10 hours. The distribution of Raman signals from cytochromes (750 cm-1), lipids (2850 cm-1), and proteins (2920 cm-1) are shown in green, red, and blue, respectively. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adn0110 Understanding the behavior of the molecules and cells that…
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Physics
New electron microscopy technique reveals complex spin structures on femtosecond timescales
Melon pair spin vector. Unlike the rapidly oscillating electric and magnetic fields of the surface plasmon polariton that underlie this spin texture, the texture itself is temporally stable over the duration of the plasmon pulse. The horizontal separation of the two (red) maxima is approximately half the wavelength of the surface plasmon polariton (390 nm). Credit: P. Dreher et al.,…
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Nanotechnology
Atomic force microscopy reveals microtubule defects with submolecular resolution
Figure 1. High-resolution AFM images of the inner and outer surfaces of microtubules. Credit: Nano Letters (2024). DOI: 10.1021/acs.nanolett.4c04294 In a study recently published in the journal Nano Letters, researchers at Kanazawa University Nano Life Science Institute (WPI-NanoLSI) used frequency-modulated atomic force microscopy to examine the inner surfaces of microtubules (MTs) and microtubules. We revealed the submolecular structure of the…
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Biology
Advanced genetic techniques and microscopy provide new insights into the symbiosis of anaerobic ciliates and methanogens
AP, representatives of the studied anaerobic ciliates and their respective methanogenic endosymbionts, please refer to the study for a complete description. Credit: Charles University Recent studies have revealed important details about the relationship between anaerobic ciliates and methanogenic archaea. This relationship has fascinated scientists for decades. Researchers from Charles University School of Science and the University of Rhode Island used…
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Science
Deep Design Produces ‘Butterfly’ Phase Mask for Light Sheet Fluorescence Microscopy
(A) With a conventional Gaussian beam, the illumination beam spreads at its edges due to diffraction. (B) Joint optimization scheme, where the network predicts the position of the beads in the focal plane. The deep learning network and the input phase mask are updated simultaneously based on a loss function. Credit: Chen Li et al. Researchers have presented a solution…
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