genes
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Science
How “jump genes” penetrate DNA during cell division
ORF1P-RNP formation and DNA recognition model. ORF1P forms higher-order oligomers with HOMO trimers that can bind to DNA but may clearly prefer RNA. Credit: Sarah Zernia et al Viruses are known to use genetic machines of invading human cells to make copies of themselves. As part of the process, the virus leaves debris throughout the human genetic material (genome). Viral-like…
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Biology
Announces Viral Protection for Bacteria: 9 Genes that Can Help Phage Therapy
Identification of the anti-permeable protection system of V. parahaemolyticus. A, V. Schematic diagram of a bioinformatic workflow for identification of anti-permeasure protection systems and determination of genomic contexts in parahaemolicatus. B, Histogram of the number of systems found in strains of V. parahaemolyticus by defensive finder. C, the number of systems identified by the defense finder according to each defense…
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Chemistry
Scientists identify 11 genes affected by PFAS, shedding light on neurotoxicity
Research led by the labs of University at Buffalo chemistry professors G. Ekin Atilla-Gokcumen and Diana Aga reveals molecular insights into the neurotoxic effects of perfluorinated and polyfluorinated alkyl substances, better known as eternal chemicals. Some clues have been revealed. Credit: Meredith Forrest Kulwicki / University at Buffalo Perfluorinated and polyfluorinated alkyl substances (PFAS) persist in water, soil, and even…
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Other Sciences
Ancient genes pinpoint when humans and Neanderthals intermingled
This image provided by the Prague National Museum shows the skull of an ancient hominin called Zlaty Kush, originally discovered in the Koněprus Cave in the Czech Republic. Credit: Marek Jantač/National Museum, Prague, via AP Neanderthals and humans likely intermingled during a narrow period of time 45,000 years ago, scientists reported Thursday. Researchers analyzed ancient genes to pinpoint when the…
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Biology
Discovery of 2,586 orphan genes in Rosa chinensis reveals stress adaptation and floral development
Steps to identify orphan genes in the R. chinensis genome. Credit: Tropical Plants (2024). DOI: 10.48130/tp-0024-0036 Orphan genes, found only in specific lineages, are important drivers of new functions and phenotypic traits. This discovery lays the foundation for understanding how roses grow under environmental challenges. Rosa chinensis, a beloved ornamental plant, is a mainstay in the horticultural world. Despite their…
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Science
Unique mRNA delivery method could repair defective genes before birth
In utero delivery of Cas9 mRNA/gRNA by ADP-LNP leads to extensive cell editing in the fetal brain. Credit: University of California, Davis New research shows that biomedical tools can successfully deliver genetic material to edit defective genes in developing fetal brain cells. The technology, tested in mice, could halt the progression of genetically based neurodevelopmental conditions such as Angelman syndrome…
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