gene
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Biology
The gene pool is dangerously shallow for many species. Researchers find five ways to support
Golden bandits (ISOODON AURATUS). Credit: Corin Sims/Biodiversity, Conservation and Attraction, CC by-Sa Before the species become extinct, their groups are often shrunk and isolated. A healthy group tends to have a large gene pool where many genetic varines circulate. However, as the gene pool of the species shrinks as the population decreases, the road to extinction erodes genetic diversity. Losing…
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Nanotechnology
End -Some Escape: Improve LNP MRNA to bend lipids and gene editing
The new lipid sample improves the success rate of the lipid nanoparticle that supplies the contents. Credit: sylvia zhang Every time a shuttle is docked by the International Space Station (ISS), a delicate dance develops between the shuttle docking system and the station counter part. Thanks to international standards, these mechanisms are universally compatible, so that astronauts and cargo can…
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Nanotechnology
AI-designed ‘nanocage’ mimics virus behavior to enhance gene therapy
Cryo-EM analysis of the designed novel protein nanocage. Credit: POSTECH Researchers have developed an innovative treatment platform by using artificial intelligence (AI) to mimic the complex structure of the virus. Their pioneering research was published in the journal Nature on December 18th. Viruses are uniquely designed to encapsulate genetic material within a spherical protein shell, allowing the virus to replicate…
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Nanotechnology
Nanoparticle-mediated gene therapy addresses a major cause of stillbirth and premature birth in guinea pig models
Dogs, cats, guinea pigs, rabbits, and ferrets have been taken to veterinary hospitals with heat stroke. Credit: Pixabay/CC0 Public Domain Billions of people living on Earth owe their lives to the temporary organs that supported and nourished them in their mothers’ wombs. The placenta, or afterbirth, is considered sacred in some cultures, and its vital role in pregnancy has been…
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Biology
‘e-Drive’: New gene drive reverses insecticide resistance in pests, then disappears
Self-killing ‘e-Drive’ reverses insecticide resistance. Credit: Bier Lab, University of California, San Diego Pesticides have been used for centuries to combat widespread pest damage to valuable food crops. Eventually, over time, beetles, moths, flies, and other insects develop genetic mutations that make the insecticides less effective. Increasing resistance from these mutants is forcing farmers and vector control professionals to increase…
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Nanotechnology
Drug delivery system overcomes circulatory obstacles that prevent gene therapy from reaching its target
Graphical summary. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.07.023 Harnessing the remarkable ability of viruses to deliver gene therapy across previously circulatory obstacles is at the heart of a University of Alberta-led discovery that promises to reinvigorate the field of genetic medicine. John Lewis, an oncologist in the School of Medicine and Dentistry and lead author of the study describing this advance,…
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