Drug
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Other Sciences
Racial gaps maintain in US juvenile drug crime cases
Credit: Pixabay/CC0 Public domain Research on race/ethnic and juvenile court processing in the United States often has more than the results of their white counter parts, and the context of the community can be conditional for this relationship. It turns out that there is sex. In a new research, researchers have been prosecuted from the perspective of the ruling and…
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Nanotechnology
Nano particles coated with peptides achieve 98% of drug filling rates and improve cancer treatment.
High filling peptide drug nanoparticle. Credit: Rein Ulijn The scientist team has developed a groundbreaking approach to improve the preparation using a specially designed peptide. This innovative method greatly enhances the antitumor effect, as it has been demonstrated by a leukemia model. The study in the CHEM magazine was led by the New York State University Graduate School of State…
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Chemistry
New synthetic technology reduces drug development time and cost
Hans Renata and Kenta Yokoi in Renata’s lab at Rice University. Credit: Alex Becker/Rice University. A team of chemists from the Scripps Research Institute and Rice University has unveiled a new method that simplifies the synthesis of piperidine, a key structural component of many pharmaceuticals. The study, published in the journal Science, combines biocatalytic carbon-hydrogen oxidation with radical cross-coupling, providing…
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Chemistry
Enzyme engineering has the potential to drive more sustainable and efficient drug manufacturing.
Credit: Nature Synthesis (2024). DOI: 10.1038/s44160-024-00671-w Researchers have discovered a new way to use biocatalysts to improve the production of critical raw materials needed for essential medicines, making the process faster, more efficient, and more environmentally friendly. Biocatalysis is a process that uses enzymes as natural catalysts to carry out chemical reactions. Scientists from the University of Manchester and AstraZeneca…
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Nanotechnology
Advances in drug delivery: A new framework linking lipid nanoparticle structure and immune responses
Diagram of receptors protruding from the cell membrane. The red molecule approaches the receptor cavity. The membrane consists of two layers of molecules, with a purple head on the outside and an orange tail on the inside. Credit: Carnegie Mellon University Chemical Engineering A new framework fills a gap in our understanding of RNA therapeutics by linking the structure of…
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Nanotechnology
Advances in nanomedicine provide precise doses of antibiotics to fight infections and drug resistance
Credit: Drug Delivery and Translational Research (2024). DOI: 10.1007/s13346-024-01708-5 Researchers at the University of Waterloo have developed a new technology that keeps the entire dose of antibiotics in one small dose and allows a given patient to receive the amount of medicine they need to fight an infection on demand. did. This breakthrough in targeted medicine is the result of…
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Nanotechnology
Drug delivery system overcomes circulatory obstacles that prevent gene therapy from reaching its target
Graphical summary. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.07.023 Harnessing the remarkable ability of viruses to deliver gene therapy across previously circulatory obstacles is at the heart of a University of Alberta-led discovery that promises to reinvigorate the field of genetic medicine. John Lewis, an oncologist in the School of Medicine and Dentistry and lead author of the study describing this advance,…
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Chemistry
Research reveals reaction mechanism between cobalt(III) and nitrile, paving the way for drug development
Graphical summary. Credit: Journal of the American Chemical Society (2024). DOI: 10.1021/jacs.4c03211 A research team led by Professor Jaeheung Cho from UNIST’s Department of Chemistry reports on the reaction mechanism between cobalt(III)-based metal complexes and nitrile materials, paving the way for new potential materials, in the Journal of the American Chemical Society Announced. drug development. In this study, the team…
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Science
UK Popper study highlights problems with proposed drug policy
Adjusted odds ratios for self-reported popper use by combination of gender and sexual orientation (full sample on the left, subsamples on the right). Source: The British Journal of Criminology (2024). DOI: 10.1093/bjc/azae055 New research into the use of the drug poppers (alkyl nitrites) has revealed contradictions in proposed changes to drug policy in the UK and how exemptions from the…
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Chemistry
AI for Drug Discovery: Streamlining Drug Discovery with DrugSynthMC
Graphical Abstract. Credit: Journal of Chemical Information and Modeling (2024). DOI: 10.1021/acs.jcim.4c01451 Scientists have devised a free AI algorithm that they believe will make drug discovery much more efficient. DrugSynthMC can generate thousands of brand new virtual drug molecules for screening and testing in seconds. It adapts to an input “target” molecule, creates a library of drug candidates to test…
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