diseases
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Nanotechnology
Cholesterol-modified oligonucleotides promise to treat brain diseases
This study revealed that by binding to lipoproteins, cholesterol-binding heteroduplex oligonucleotides (chol-hdos) can stay in the bloodstream for longer and reach brain tissue much more effectively than the counterpart of antisense oligonucleotides (ASOs). These findings pave the way for the development of brain-targeted gene regulatory drugs. Credit: Tokyo University of Science, Nishikawa, Japan Taking medications past the blood-brain barrier has…
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Nanotechnology
Nanoliposomes pave the way for treatment of rare genetic diseases
Indication of new nanoGLA therapy. We demonstrate its composition and structure by cryomicroscopic imaging. NanoGLA has been injected into mice and has orphan drug designation. Credit: ICMAB An international research team has developed a new nanotechnology-based therapy called nanoGLA for the treatment of Fabry disease. This new treatment has shown significant efficacy in preclinical studies. The study was published in…
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Nanotechnology
Delivering mRNA- and RNAi-based therapies in a single treatment has the potential to fight complex diseases
Simultaneous gene recovery and knockdown with single-drug NPs and co-delivered dual-drug NPs using mRNA and siRNA in two cell lines. Credit: ACS Nanoscience Au (2024). DOI: 10.1021/acsnanoscienceau.4c00040 Researchers at the University of Ottawa may have cracked the code for harnessing both mRNA and RNAI-based therapies to improve treatments for cancer, cardiovascular disease and other complex diseases. The success of COVID-19…
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Chemistry
A simple model system can disassemble fibrils and study therapeutic drugs for neurodegenerative diseases
Credit: Journal of the American Chemical Society (2024). DOI: 10.1021/jacs.4c11285 The causes of many diseases, such as Alzheimer’s disease and Parkinson’s disease, are found at the molecular level, or proteins, in our bodies. In healthy systems, these proteins are responsible for numerous physiological functions. They can also assemble into groups of many proteins to perform specific tasks. Once the job…
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