delivery
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Nanotechnology
In vivo 3D printing with sound is promising for accurate drug delivery, wound healing and more
A schematic diagram of the Disp (deep in vivo sound printing) platform developed by a team led by Caltech. This technology is combined with low-temperature sensitive liposomes equipped with ultrasound and crosslinking agents. Liposomes were embedded with polymer solutions containing the monomers of the polymer of interest, imaging contrast agents that reveal when crosslinking occurred (here, gas vesicles were used),…
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Nanotechnology
Modular protein adapter technology enables exosome-based precision drug delivery
Credit: ACS Nano (2025). doi: 10.1021/acsnano.4C15441 The collaborative research team has developed a modular protein adapter technology that allows for stable attachment of various substances to the surface of extracellular vesicles (exosomes). It was designed to allow functional molecules to efficiently bind even in complex environments of the cell membrane. This study demonstrated the potential for developing customized therapeutics. The…
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Nanotechnology
Q&A: Microscope “Traffic Jam” Solutions Stimulate New Insights on Particle Movement and Drug Delivery
Stewart Mallory, an assistant professor of chemical and chemical engineering in Pennsylvania, leads a research group studying active problems, particularly collective behavior of self-administered microscopic particles. Credit: Michelle Bixby / Pennsylvania From microscope robots that can carry drugs within the human body to small particles that can detect and decompose microplastics, a new field called active matter is turning to…
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Biology
Smart Delivery Tech increases CRISPR efficiency and restores mouse vision
Credit: Cell (2025). doi: 10.1016/j.cell.2025.03.015 Researchers from Helmholtz Munich and the Institute of Technology Munich have developed an advanced delivery system that transports gene editing tools to live cells more efficiently than before, based on the CRISPR/CAS9 gene editing system. Their technology, Envlpe, uses engineered non-infectious virus-like particles to accurately correct bad genes. The system also retains the possibility of…
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Nanotechnology
Scientists demonstrate preconcept proof of concept for next-generation DNA delivery technologies
Credit: Cell Reports Medicine (2025). doi: 10.1016/j.xcrm.2025.102035 Scientists at Dr. David B. Weiner’s Wistar Institute Lab explain next-generation vaccination technology that combines plasmid DNA with lipid nanoparticle (LNP) delivery systems. This study was conducted in collaboration with scientists at the University of Pennsylvania Perelman School of Medicine and the ready-made biotechnology company INOVIO, a research institute in Dr. Norbert Paldi.…
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Nanotechnology
A novel class of zwitterionic phospholipids promotes mRNA delivery
Polar electron microscope images of lipid suspensions composed of DOPE-C8 and POPC. Credit: Advanced Science (2025). doi:10.1002/advs.202413016 A new study conducted by researchers at Hokkaido University has announced a new class of zwitterionic phospholipids that can significantly enhance the functional delivery of mRNAs. This study was published in Advanced Science. The new phospholipid, dope CX, was derived from a compound…
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Physics
A salt pinch can steer colloids to improve purification and drug delivery
Credit: Pixabay/CC0 Public Domain The ability to better manipulate particles suspended in liquids can lead to better water purification processes, new drug delivery systems, and other applications. According to Yale researchers, a key ingredient is the pinch of salt. The research team led by Professor Amir Pahlavan published the results in a physical review letter. The diffusion-like phenomenon moves suspended…
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Nanotechnology
A novel ferritin-based siRNA delivery system demonstrates the potential for targeted glioblastoma therapy
Schematic representation of the design, screening, and application of ferritin-based siRNA carriers for targeted glioblastoma therapy. Credit: Fankelon’s Group A new research led by a professor. Fang Kelong and Yang Siyun of the Institute of Biophysics at the Chinese Academy of Sciences will introduce a new ferritin-based delivery system for small interfering RNAs (siRNAs) targeting glioblastoma (GBM). Published in Science…
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Science
Next-generation mRNA vaccine delivery system uses biodegradable polymers
Schematic representation of MRNA expression, T cell immune activation, and neutralizing antibody formation induced by polymers synthesized from a variety of monomers. Credit:Postech The research team at Postech has developed a biodegradable polymer-based delivery system that efficiently transports mRNA. This study was recently published in Biomaterials. Since the Covid-19 pandemic, global interest in mRNA vaccines has skyrocketed. Among existing delivery…
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Nanotechnology
Biodegradable nanoparticles enable simultaneous delivery of two drugs to attack tumors
Talazoparib increased PD-L1 expression levels and P-selectin expression evaluation in human and mouse melanomas and BRCA-mutant mouse BC. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adr4762 Researchers at Tel Aviv University have developed a new platform that uses polymer nanoparticles to deliver drug pairs to specific types of cancer, such as skin cancer and breast cancer. The researchers explain that having both…
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