cryofixed

Chemistry

Enhanced Raman microscopy enables clearer chemical imaging of cryofixed samples

Raman image of snap-frozen HeLa cells with high signal-to-noise ratio and wide field of view. Image acquisition time was 10 hours. The distribution of Raman signals from cytochromes (750 cm-1), lipids (2850 cm-1), and proteins (2920 cm-1) are shown in green, red, and blue, respectively. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adn0110 Understanding the behavior of the molecules and cells that…