covalent
-
Chemistry
Covalent bonds link lysine and cysteine to proteins under oxidative conditions and stabilize them
NOS bridge observed in the crystal structure of the Clostridium botulinum neurotoxin serotype A2 cell binding domain. Credit: University of Bath A paper by Matthew D. Lloyd, Kyle S. Gregory, and K. Rabbi Acharya entitled “The Functional Implications of Abnormal NOS and Sonos Covalent Bonds found in Proteins” has been published in Chemical Communications. Proteins are formed in cells by…
Read More » -
Chemistry
An efficient selection platform enables discovery of novel lysine targeting covalent inhibitors
Credit: Pixabay/CC0 Public Domain In a study published in Angewandte Chemie International Edition, the researchers integrated activity-based protein profiling (ABPP) data with covalent DNA-encoding chemical library (Codel) technology to identify structurally novel lysine target covalent inhibitors with diverse mechanisms of action. The team is led by Lu Xiaojie of the Shanghai Institute of Materials and Media, China Academy of Sciences,…
Read More » -
Nanotechnology
Covalent organic frameworks show great potential for efficient energy transport
Laura Spieth examines one of the COF thin films investigated in the study. Credit: Florian Wolf An interdisciplinary research team from LMU, Technical University of Munich (TUM) and the University of Oxford has used a new spectroscopic technique to investigate the diffusion of excited states in covalent organic frameworks (COFs). These modular materials can be tailored to desired properties through…
Read More » -
Chemistry
Study reveals that cobalt ions, rather than the covalent organic skeleton itself, promote catalytic activity
a) Schematic diagram of the synthesis of TpBpy-Co COF. b) PXRD patterns of TpBpy and TpBpy-Co (Cu Kα1). c) N2 adsorption (filled) and desorption (empty) isotherm profiles at 77 K. Credit: Advanced Science (2024). DOI: 10.1002/advs.202413555 Covalent organic frameworks (COFs) are less stable catalysts than previously thought, but they maintain high activity. COFs are promising designer catalysts, including in the…
Read More » -
Chemistry
The discovery of a stable single-electron covalent bond between two carbon atoms substantiated a century-old theory.
Using an X-ray diffraction instrument to study sigma bonds. Photo courtesy of Yusuke Ishigaki A covalent bond is a bond in which two atoms join together by sharing a pair of electrons, forming the basic backbone of most organic compounds. In 1931, Nobel laureate Linus Pauling suggested that covalent bonds formed from a single unpaired electron could exist, but that…
Read More » -
Nanotechnology
Researchers develop new covalent organic framework for precise targeting of cancer treatment
Credit: ACS Applied Materials & Interfaces (2024). DOI: 10.1021/acsami.4c10812 A team of researchers at New York University Abu Dhabi (NYUAD), led by Chemistry Program Director Ali Trabolsi, has developed nanoscale covalent organic frameworks (nCOFs), crystalline organic polymers modified with peptides, to treat the most aggressive form of breast cancer called triple-negative breast cancer (TNBC). The peptides enable the COF to…
Read More »
