Compounds
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Chemistry
Optimized enzymes promote nitrogen nitrogen bonds to produce bioactive compounds
Graphical abstract. Credit: ACS Catalyst (2025). doi: 10.1021/acscatal.5C01237 Microorganisms produce all kinds of materials that can act as potential agents to combat bacteria and fungi. International research teams identify and optimize enzymes that can specifically generate specific functional groups of these natural substances, expanding the toolkit of potential agents. Researchers led by Professor Sandy Schmidt (University of Groningen, Netherlands) and…
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Chemistry
Innovative synthetic technology unlocks new classes of planar organometallic compounds
Coordination chemistry of annulenes, porphyrins and related compounds. Credit: Nature (2025). doi: https://doi.org/10.1038/S41586-025-08841-2 Since the 1950s, organometallic chemistry has been a widely explored field, as there are six Nobel Prizes in the category. However, the discovery of a new class of organometallic compounds remains a rare occurrence. A team of researchers from China and the US decided to change it…
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Chemistry
Active compounds in Piper Longum Fruits demonstrate functional food and drug potential
Discovery of dimeric amide alkaloid enantiomers through molecular network-based regulatory complimentary strategies from Piper Longum Fruits and their biological activities. Credit: Haji Akber Aisa’s Team Professor Piper Longum’s mature or nearly mature fruits are used as spices and are rated by traditional Chinese herbal medicines for commercial and industrial applications, as well as multiple benefits such as dispelling and relieving…
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Chemistry
Chemical analysis of codonopsis lanceolata roots shows important vasodilatory effects from compounds
codonopsis lanceolata roots and their major compounds. Credit: Dr. Kikuchi The research group led by Professor Wai Lee, Pharmacy Professor at Tohhon University, along with Professor at the Faculty of Pharmacy Science at Eastern University, is a collaboration between Professor Sugiyama Atsuiyama from the Faculty of Pharmacy Science at the Faculty of Medicine, and the Industrial Association Collaboration It’s the…
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Chemistry
Creating groundbreaking light-driven major drug compounds from researchers
Credit: Chem (2025). doi: 10.1016/j.chempr.2025.102488 Researchers from Indiana University and Wuhan University in China have announced a groundbreaking chemical process that can streamline the development of pharmaceutical compounds, chemical building blocks that affect drug interactions with the body. Their research published in Chem describes a novel light-driven reaction that efficiently produces tetrahydroisoquinoline, a group of chemicals that play an important…
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Chemistry
Japanese plants produce compounds that exhibit potent anti-HIV activity
Structure of previously undescribed daphnene diterpenoids isolated from D. pseudomezereum.. Credit: Dr. Wei Li Researchers have discovered that Daphne Pseudomezereum (commonly known as Onishibari) contains substances that inhibit human immunodeficiency virus (HIV) replication. The plants were grown in the Medicinal Plant Gardens of the Faculty of Pharmaceutical Sciences at Tohhon University. This finding is expected to lead to the discovery…
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Chemistry
Synthetic methods unlock the pathway to valuable fluorinated drug compounds for new drugs
Electrostatic latent maps of isosteric oxatane, α, α-difluoro-oxetane and β-lactones. Credit: Nature Chemistry (2025). doi:10.1038/s41557-024-01730-7 Researchers at the National University of Singapore (NUS) have pioneered a new catalytic transformation that converts epoxides to fluorinated oxane. By unlocking the path to these valuable drug scaffolds, this discovery could potentially open the door to new drugs for drug discovery applications. The research…
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Chemistry
A new approach identifies reproducible volatile organic compounds for lung cancer diagnosis
Supplementary cover. Credit: Analytical Chemistry The researchers have developed a multimedia approach (MMA) to identify reproducible volatile organic compounds (VOCs) in lung cancer cells. This study, published in Analytical Chemistry, provides new insights into non-invasive lung cancer diagnosis through VOCs. VOCs of human odor have been an important focus of health research, particularly for screening for non-invasive lung cancer. Despite…
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Biology
How volatile organic compounds strengthen plant defenses and provide sustainable pest control solutions
Plants that are attacked or infested by pests emit VOCs that send signals to nearby healthy plants. This strengthens and improves the defense mechanisms of neighboring plants against pests and pathogens. Credit: Genichiro Arimura / TUS, Japan Volatile organic compounds (VOCs) are important airborne signals or odors that allow plants to communicate with other organisms and plants over short and…
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Chemistry
Natural compounds in flowers block the activity of enzymes linked to multiple sclerosis and cancer
Structure of flavonoids extracted from dahlia and coreopsis flowers. Red boxes indicate similarities between compound structures and sulfretin (A), and blue boxes indicate differences. Credit: Journal of Biological Chemistry (2024). DOI: 10.1016/j.jbc.2024.107916 Scientists have identified a natural compound that halts processes involved in the development of certain forms of cancer and demyelinating conditions, such as multiple sclerosis, that damage the…
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