Nanotechnology

Scientists reveal how microswimmers move faster in groups and how to pave for small drug-inducing robots

The artistic impression of a microswimmer (orange sphere) passing through a trapped liquid crystal environment. The green rod represents the aligned molecular structure of the liquid crystal, which guides and influences the movement of the swimmer. Credit: Loughborough University

Scientists have revealed how small swimming cells, such as sperm and bacteria, can move quickly as they migrate as groups. This study revealed that it could accelerate the development of microscopic robots that supply drugs to specific areas of the body.

The study, conducted by researchers at Loughborough University and the Institute of Science in India, shows that when “microswimmers” move together through an enclosed environment, they change the properties of the surrounding liquid, reduce resistance, and increase speed by swimming alone.

Findings may be key to the design of artificial microswimmers that can be used for a variety of medical applications, including IVF, parasite treatment, and targeted medical drug delivery to replace traditional, fewer accurate interventions.

“Imagine if we can create artificial microswimmers that can be injected into the bloodstream and controlled externally. We can navigate them to specific areas, such as cancer cells, and only deliver the drug to these areas.”

“To do this, we first need to understand how naturally occurring microswimmers navigate different fluid environments. This research has made great strides in this field.”

This study, published in a physical review letter, focuses on the theoretical model of paramesium. This is a small, single-celled organism that lives in the water and propels itself by hitting hair-like structures called cilia. Their movements are similar to those of sperm and other microswimmers, using appendages to generate movements and navigate the fluid environment.

Using computer simulations and theoretical models, researchers analyzed how individual microswimmers and up to 10 groups move through a limited liquid crystal environment. These structured liquids occur naturally in natural and biological systems, including cell membranes and tissues.

Scientists reveal how microswimmers move faster in groups and how to pave for small drug-inducing robots

(a) Schematic diagram of the surface velocity of the slider. The orientation is expressed by arrows and background color (see color bars), for typical pushers (β=-2), neutrals (β=0), and pullers (β=2). (b) Schematic diagram of a system consisting of a single spibar suspended from a fixed nematic liquid crystal surrounded by two parallel walls. Geometric and dynamic quantities are shown. The bulk director field is oriented along the Z axis due to the strong homotropic anchors on both walls. (c) The nematic director field around the squir features a defect in the Saturn ring (55) due to the homeotropic anchor on the surface of the sarkya (55). Credit: Physics Review Letter (2025). doi:10.1103/physrevlett.134.128302

The key findings are as follows:

Microswimmers that move in groups help you swim more efficiently by reducing resistance and increasing propulsion. With more swimmers participating, the average speed increases and you can move faster on your own. The LCD environment helps instructing and direct movements of Micro Swimmer. There are two types of micro swimmers: “pusher” and “puller”. Pushers benefit from collective movements, but pullers are hampered by one another and the effect depends on the swimmer type.

The next step is to expand research that moves from small-scale simulations to something that replicates how hundreds of microswimmers move through different sealed environments.

Scientists also hope to work with paramesium and other types of microswimmers to collaborate with experimental researchers to compare real-world behavior with theoretical models. This gives you deeper insight into the collective swimming dynamics and can inform the design of artificial microswimmer.

Professor Tony Croft, one of the research authors and professor emeritus of mathematics education at Loughborough University, hopes that the impact of this study will be felt beyond academic discipline.

“The work has the power to ignite the curiosity of young minds and inspires a new generation of learners who explore the fascinating intersections of mathematics, physics and biology,” he said.

“In many cases, students perceive mathematics as dry and irrelevant. Our work unveils the potential to challenge the concept and unlock deep connections with the real world and exciting new discoveries.”

Dr. Shubhadeepmandal, the lead author of the Indian Institute of Science, said, “In this study, we will investigate how important properties of complex liquids, such as anisotropy and elasticity, affect the movement of swimming entities such as motile cells and synthetic tracers. Properties that control movement in these complex liquids.”

Tom Mason, PhD student and research co-lead author of one of the authors of the Loughborough University, said, “Our research on nematic microswimmers in limited environments affects both understanding of active substances in complex liquids and both basic physics and real-world applications. By providing swimmer dynamics, confinement, and interlacing into the dietary environment of nematic elastomers, it affects both basic physics and real-world applications, including microfluidics, biomedical engineering, and soft physics.

“We have identified wall hovering, vibration, and central movement (wall hovering, vibration, and central movement) that provides a framework for controlling the microscale motion of liquid crystal media. These findings have potential applications in target drug delivery, microrobotics, and synthetic biological systems. Interactions.”

Details: Shubhadeep Mandal et al., Cooperationality of Confined Nematic Microswimmers: One to Many Physics Review Letters (2025). doi:10.1103/physrevlett.134.128302

Provided by Loughborough University

Quote: Scientists reveal how microswinmers move faster in groups, paved for a small drug-inducing robot (2025, March 28), obtained from March 31, 2025 from https://phys.org/news.

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