Researchers develop miRNA-tunable living interface for neurovascular remodeling

LIFES design. LIFES transmits topographic, piezoelectric, and photopyroelectric signals for cellular modulation, allowing fine-tuning of exosome secretion and promoting neurovascular remodeling. Credit: SIAT
A research team led by Dr. Du Xuemin from the Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, reported a living interface with the unique feature of sustained secretion of bioactive exosomes with tunable content and miRNA cargo. It effectively promoted neurovascular remodeling. .
The study was published in Matter on November 21.
Neurovascular remodeling is critical for restoring normal function in regenerated tissues and engineered organs, and this requires multiple targets and phase-specific paracrine regulation. However, existing strategies still fail to mimic such dynamic and complex paracrine regulatory effects in native physiological processes, hindering synergistic neurovascular remodeling.
Exosomes, as important players in natural paracrine processes, have shown great promise in neurovascular remodeling, but they still face challenges. Direct administration of exosomes is limited by their short shelf life (24–48 hours). Furthermore, exosome delivery systems struggle to preserve bioactivity and maintain adaptable miRNA cargo throughout the release period, limiting their effectiveness at various stages of neurovascular remodeling.
The living interface for fine-tuned exosome secretion (LIFES) proposed in this study is a poly(vinylidene fluoride-co- It consists of two core elements: an intelligent material layer based on trifluoroethylene. , a living cell layer containing rat bone marrow-derived mesenchymal stem cells (MSCs) for efficient biogenesis of exosomes.
The synergistic interaction between the two core elements allows LIFES to secrete bioactive exosomes in a sustained (approximately 192 h) and stage-specific manner, with tunable content (approximately 8-fold increase) , with a programmable miRNA cargo (initially pro-angiogenic and later pro-angiogenic). – neuropathic).
“Phase-specific exosome secretion of LIFES meets physiological requirements, which is consistent with the native multi-target and multi-step paracrine regulatory effects observed in physiological neurovascular remodeling processes,” Dr. Du said.
By mimicking natural paracrine regulatory effects within the natural physiological process of neurovascular remodeling, LIFES effectively promotes reorganization of vascular neural networks, even in challenging diabetic wound models .
This research opens new avenues for next-generation intelligent materials, revolutionizing biomedical devices, regenerative medicine, and brain-machine interfaces.
Further information: Mingxing Peng et al, “Ferroelectric living interface for fine-tuned exosome secretion towards physiomimetic neurovascular remodeling”, Matter (2024). DOI: 10.1016/j.matt.2024.10.019
Provided by Chinese Academy of Sciences
Citation: Researchers Develop miRNA Tunable Living Interface for Neurovascular Remodeling (November 22, 2024) https://phys.org/news/2024-11-mirna-tunable-interface-neurovascular Retrieved November 22, 2024 from -remodeling.html
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