Nano particles coated with peptides achieve 98% of drug filling rates and improve cancer treatment.

High filling peptide drug nanoparticle. Credit: Rein Ulijn
The scientist team has developed a groundbreaking approach to improve the preparation using a specially designed peptide. This innovative method greatly enhances the antitumor effect, as it has been demonstrated by a leukemia model. The study in the CHEM magazine was led by the New York State University Graduate School of State Center (CUNY ASRC) and researchers at the Sloan Ketaling Memorial Cancer Center.
The drug delivery system often faces two important tasks: low solubility and inefficient delivery in the body. Many drugs are difficult to melt, making it difficult to reach the target target. Furthermore, the current delivery system is wasted a considerable part of the drug during the preparation, only 5 to 10% of the drug is filled normally, and the therapeutic effect has decreased.
Peptide helper
The research team has developed a new solution by designing a peptide (a short string of amino acids) that combines a specific drug to create a nanoparticle for therapeutic treatment. These nanoparticles are mainly composed of drugs, with thin peptide coating that improves solubility, enhances the stability of the body, and optimizes delivery to target areas. It should be noted that this approach has achieved up to 98% of drug filling rates, which has dramatic improvements compared to conventional methods.
By combining computer models and clinical tests, new drugs/peptodonano particles have been identified. They subsequently demonstrated the remarkable results in leukemia models. Nano particles were more effective in reducing the tumor than the drug alone. In addition, the efficiency can reduce the dose of drugs and reduce side effects.
“The peptide, which is a molecular element made from the same components as our protein, is very useful,” he said, “The Director of the Nanocae Initiative of New York State University ASRC, and the University of Hunter University. Professor Rainwolin said. “We believed that they could be useful to solve the two major problems found in many drugs, the low solubility and the inefficiency of delivery. By designing the peptide to bind to, we were able to create a very highly filled nanoparticle.
Customized technology
This innovation has great potential because it can customize peptide to enhance the effectiveness of various drugs. Since the possibility of interaction in peptide design is extensive, it may be possible to adjust the peptide according to a specific drug and expand its application to other than cancer treatment.
“With this groundbreaking progress, the development of higher -precision pharmaceuticals will be possible,” said Daniel Heller, Chief Researcher of Daniel Heller, General Manager of Cancer Nano Medical Laboratory, a commemorative throne ketaling cancer center molecular pharmacology program. I mentioned. “By using a specially designed peptide, you can build a nano -drug that enhances the effects of existing drugs and reduce toxicity, and develop drugs that may not work without these nanoparticles. It will be possible.
NAXHIJE “GIA” Berisha, formerly New York State University Graduate School Center Ph.D. Students who did many experimental work have emphasized the possibility of peptide plan. “We used an experimental test to identify promising peptides and used a calculation modeling to analyze the interaction with the treatment molecule,” she said. The possibility that an array may match a specific drug suggests that there is a possibility that there is a peptide that matches all drugs, and it may revolutionize the drug delivery method. “
Looking at the future
The research team is currently adopting a lab automation method to further improve and accelerate peptide and drug matching processes. Their next steps include verifying the potential of this approach in widespread diseases. Successful innovation can lead to more effective treatments, side effects, and significant costs for pharmaceutical development.
Detailed information: NAXHIJE BERISHA ET AL, drug conforming oligopeptide direct discovery of high -filled nano -aggregate, CHEM (2025). Doi: 10.1016/j.chempr.2024.102404
Magazine information: Chemistry
Provided by New York University Advanced Science Center
Quoted: Nano particles coated with peptides achieve 98% of drug load and improve cancer treatment (January 24, 2025) https://phys.org/news/2025-01-Peptide- Acquired from coated-nanoparticles-drug-Cancer on January 25, 2025. html
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