Compounds from Mitragyna diversifolia have antidiabetic and antioxidant potential
Credit: Biomedicine and Pharmacotherapy (2024). DOI: 10.1016/j.biopha.2024.117450
Mitragyna diversifolia is an evergreen shrub or small tree that grows up to 5 m in height and is found in humid forests and disturbed habitats. Available phytochemical studies suggest that the main components of M. diversifolia are triterpenoids and alkaloids.
In a study published in the journal Biomedicine & Pharmacotherapy, researchers from the Xishuangbanna Tropical Botanical Garden (XTBG) of the Chinese Academy of Sciences isolated a compound from the branches of Mitragyna diversifolia and investigated its potential anti-diabetic and antioxidant properties. I investigated.
They isolated 16 compounds, including 12 triterpenoids (1–12), one phenolic compound (13), and three flavonoids (14–16).
“Compounds 1-7 and 10-16 were isolated for the first time from M. diversifolia,” said Zhang Yumei, corresponding author of the study and researcher at XTBG.
Previous studies have shown that inhibiting alpha-glucosidase activity and increasing glucose uptake by organs and tissues is an important strategy for maintaining adequate blood sugar levels in patients with type 2 diabetes mellitus (T2DM). is shown.
The researchers evaluated the biological activity of these compounds using α-glucosidase inhibition assays, molecular docking experiments, and glucose uptake experiments.
They used a web-based pharmacological analysis platform to identify diabetes-related target proteins. Subsequently, two candidate targets, albumin (ALB) and peroxisome proliferator-activated receptor gamma (PPARG), were identified that may be associated with its therapeutic efficacy.
Researchers found that compounds isolated from branches of Mitragyna diversifolia exhibit significant anti-diabetic and antioxidant activity.
In particular, compounds 7, 14, and 15 showed strong inhibitory effects on α-glucosidase, and compound 14 was able to significantly promote the glucose uptake rate in 3T3-L1 adipocytes. In addition, compounds 13, 14, 15, and 16 also showed strong antioxidant capacity.
“Our study reveals specific antidiabetic and antioxidant substances in M. diversifolia and suggests that compound 15 could be developed as a potential natural antidiabetic and antioxidant agent. “We showed that,” Zhang Mengmei said.
Further information: Jing Lu et al, Exploration of potential antidiabetic and antioxidant components and possible mechanisms from branches of Mitragyna diversifolia, Biomedicine & Pharmacotherapy (2024). DOI: 10.1016/j.biopha.2024.117450
Provided by Chinese Academy of Sciences
Citation: Compounds from Mitragyna diversifolia have antidiabetic and antioxidant properties (October 14, 2024) https://phys.org/news/2024-10-compounds-mitragyna-diversifolia-harbor-antidiabetic. Retrieved October 14, 2024 from html
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